Philipp SteigerProduct Design Engineering BSc
Disposable Mist Bioreactor
The disposable mist bioreactor introduces a sterile and efficient production of hairy root cultures and their secondary metabolites for the pharmaceutical and cosmetic industry, without the contamination from pesticides and fertilisers. A focus point of the project was the handling during setup, inoculation and harvest. As the handling within a laminar flow cabinet is restricted, the geometry of the internal structure improves the handling during these processes. The project also had a focus on improving the spread of mist across the root cultures within the reactor. This was tested with complex computational fluid dynamics simulations. The final geometry has yet to be verified at ROOTec bioactives Ltd with root cultures under sterile conditions.